A clinic-pathologic diagnosis of Cronkhite-Canada syndrome (CCS) was made based on the above findings.

CCS is a rare, non-hereditary disease characterized by widespread GI polyposis and ectodermal abnormalities [1]. The diagnosis of CCS should be based on characteristic clinical, endoscopic, radiologic and histologic findings [2]. GI symptoms and ectodermal abnormalities were prominent in this patient. Endoscopy showed typically CCS polyps that distributed among the entire GI tract except oesophagus [3]. It is necessary to differentiate CCS from other GI polyposis syndromes such as Peutz-Jeghers syndrome, juvenile polyposis syndrome, Gardner syndrome and Turcot syndrome when polyposis of GI tract is noted under endoscopy [4]. The diagnosis of CCS is usually delayed due to low incidence and unrecognized phenotype. Although not considered as a malignant disorder, the mortality of CCS is high, mainly due to complications such as GI bleeding, malabsorption and rectal prolapse [2]. In this case, the patient suffered from severe osteoporosis and osteomalacia due to the deficiency of vitamin D. To the best of our knowledge, flail chest caused by CCS has not been described in the literature up to now.

Considering the high mortality of CCS due to diverse complications, it is important to achieve early diagnosis and appropriate treatment. Thus, we suggest gastroenterologists be cognizant of the typical manifestations and diagnostic methods to better identify CCS. Gastroenterologists should also be aware of the potential danger of CCS-related osteoporosis and osteomalacia for better disease management.