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Kante, Sahu, Kedia, Vuyyuru, Soni, Singhal, Sharma, Makharia, and Ahuja: Efficacy and tolerability of hyperbaric oxygen therapy in small bowel stricturing Crohn’s disease: a pilot study

Abstract

Background/Aims

Existing therapeutic options for complicated Crohn’s disease (CD) like biologics and surgery are limited by inadequate long-term efficacy, cost, and adverse effects. Tissue hypoxia is important in CD pathogenesis and may be ameliorated with hyperbaric oxygen therapy (HBOT). We assessed the efficacy and tolerability of HBOT in small bowel stricturing CD.

Methods

This pilot study included patients of small bowel stricturing CD (from April 2019 to January 2020) who underwent HBOT. These patients were refractory to conventional medical treatment or had multiple strictures not amenable to resection. Each session of HBOT was given for 60 minutes with a pressure of 1.5-2.5 atm. Clinical, biochemical responses and Short Inflammatory Bowel Disease (SIBD) questionnaire were evaluated at 2 and 6 months, and radiological response was evaluated at 6 months.

Results

Fourteen patients (mean age, 42.9±15.7 years; male, 50%) were subjected to 168 HBOT sessions. Thirteen patients (92.7%) had strictures and 1 patient had enterocutaneous fistula in addition. Median number of HBOT sessions was 11 (range, 3-20) which were administered over a median of 4 weeks. Most patients tolerated it well except 1 who had hemotympanum. At 2 and 6 months of follow-up, 64.2% of patients had a clinical response, 50% and 64.2% of patients had clinical remission respectively. Steroid-free clinical remission was seen in 8 (57%) of patients with radiological improvement in 50%. There was a significant improvement in SIBD scores at 2-month follow-up (59.4 vs. 44.5, P=0.03).

Conclusions

HBOT can be a safe and effective therapeutic option in patients with stricturing small bowel CD refractory to conventional medical treatment.

INTRODUCTION

Crohn’s disease (CD), is a chronic relapsing-remitting inflammatory disorder of the gastrointestinal tract [1]. Most patients with CD present with an inflammatory phenotype but a significant portion of them eventually progress to a complicated stricturing/fistulizing disease [2,3]. Population-based studies reported the probability of progression to stricturing CD as about 15% at 10 years and 21.6% at 20 years [4].
Complicated CD patients often have a poor quality of life and may experience repeated hospital admissions, multiple operations, poor nutrition and malignancy. Medical therapies of CD include immunosuppression with steroids, thiopurines, anti-tumor necrosis factor (TNF) therapy, and newer biologicals. All these therapies have adverse effects, limited evidence of success especially in the setting of stricturing disease and patients may still progress to surgery after receiving all these drugs [2]. Despite the revolutionary emergence of biologic agents over the past decades, estimates for the surgical resection of stricturing disease have either remain unchanged or have shifted from less emergent to a more elective procedure [5,6]. Surgical options include bowel resection, strictureplasty and fistula repair all of which involve surgical morbidity and mortality. About 40% to 70% of patients overall require surgical treatment 10 years after diagnosis [7]. Unfortunately, postoperative recurrence is common and can lead to repeated surgical intervention [8]. So the treatment of stricturing and fistulizing CD still remains a therapeutic challenge.
Hyperbaric oxygen therapy (HBOT), works on the fact that chronic hypoxia is 1 of the mechanisms of chronic inflammation in inflammatory bowel disease (IBD). HBOT provides 100% oxygen under raised pressures, which increases tissue oxygen levels, relieves hypoxia and alters inflammatory pathways. In other human studies and model systems, HBOT has been demonstrated to inhibit neutrophil adhesion and pro-inflammatory cytokines (interleukin-1, interleukin-6, and TNF-α) pro-duction, improve hypoxia tolerance through upregulation of response pathways (hypoxia inducible factor-1α and heme oxygenase-1), and enhance wound healing through increased growth factor synthesis and migration of stem cell progenitors from the bone marrow [9,10]. Though the use of HBOT was dated before the biological era, with the growing acceptance of biological therapy, HBOT studies remained in infancy. A recent systematic review showed that HBOT is a safe and well-tolerated treatment option both for CD and ulcerative colitis (UC) [11,12]. A recent study also showed its therapeutic effect in healing pouch related complications which were refractory to medical treatment including biologicals [13].
There is no data to show the effect of HBOT in patients with stricturing small bowel CD which is difficult to treat with currently available treatment options. So, the present study was planned to study the efficacy and safety of HBOT in patients with stricturing small bowel CD refractory to conventional medical therapy.

METHODS

1. Study Design

This is a single-center, prospective, pilot study conducted at the Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi.

2. Study Population

All patients with small bowel stricturing CD hospitalized or following up at the IBD Clinic in the Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi were screened for inclusion. Patients between 18 and 65 years of age with active stricturing disease on magnetic resonance imaging (MRI) and who were refractory to medical treatment were included. Patient having any complication requiring urgent surgical intervention and pregnant or nursing women were excluded. Patients having contraindications for HBOT like claustrophobia, middle ear disorders, severe chronic obstructive pulmonary disease with CO2 retention, history of pneumothorax, pacemaker or implantable cardioverter defibrillator in situ and uncontrolled seizures were excluded.

3. Assessment of Patients

The clinical assessment included patient’s demographic features, symptoms, and previous treatment history. For disease characterization, endoscopic and imaging features were noted. Baseline laboratory investigations include complete hemogram, liver function tests, and kidney function tests. To rule out contraindications for HBOT, relevant history of any pulmonary, cardiac, neurological, ear, nose systems, and claustrophobia were asked. ENT (ear, nose and throat) evaluation, electrocardiogram, and chest X-ray were done before HBOT. Baseline Crohn’s Disease Activity Index (CDAI) and Short Inflammatory Bowel Disease (SIBD) questionnaire [14] were recorded for all the patients.

4. Intervention

After screening and informed consent, patients were subjected to HBOT. Monoplace hyperbaric chamber (Bara Med; Environmental Tectonics Co., Southampton, PA, USA) which allows a single person to lie down supine and subjected to 100% oxygen under high atmospheric pressure was used. Patient could be continuously contacted through a phone receiver by a person sitting outside. All patients were instructed not to hold breath during compression or decompression. The duration of each therapeutic session of HBOT was 1 hour. Pressures were gradually increased from 1 ata to preset atmospheric pressure (range, 1.5-2.5 ata) under 100% oxygen. During the procedure, if the patient experienced any discomfort or adverse effect, the session was stopped and necessary steps were taken immediately. Post-procedure the patients were monitored closely for any adverse effects.

5. Follow Up

CDAI scores, SIBD scores, hemoglobin and albumin values were noted at 2 months and 6 months of follow-up to assess clinical response. At 6 months of follow-up repeat magnetic resonance enterography was done in patients who had clinical response to assess the imaging response.

6. Definitions

1) Crohn’s Disease

Diagnosis of CD was made as per European Crohn’s and Colitis Organisation guidelines, based upon characteristic clinical, radiologic, endoscopic, and histologic features [15]. Disease activity was measured by the CDAI [16]. Disease location and behavior were classified based on Montreal classification [17].

2) Definitions of Stricture

It is a lesion with a combination of a reduction of luminal narrowing > 50%, an increase in bowel wall thickness > 25% relative to non-affected bowel and pre-stricture dilation > 3 cm. For strictures identified during endoscopy, strictures were defined by luminal narrowing with an inability to pass the endoscope across the narrowing [18].
Clinical remission and response was defined as patients having complete resolution of symptoms with CDAI < 150 and decrease in CDAI by 100 points respectively, whereas active disease was defined by symptomatic patients with disease activity CDAI > 150.

3) Non-Perianal Fistulizing CD

Presence of enteroenteric, enterocutaneous, vesico-rectal, or vagino-rectal fistula with active discharge. For enterocutaneous fistula, complete response was defined as 100% decrease in discharge with complete closure of fistulous openings and partial response as ≥ 50% decrease in the number of fistulous openings or ≥ 50% decrease in fistulous discharge (in case of single fistula) [19].

4) MRI Response

There is no gold standard MRI-based activity score in patients with CD. Several scores have been used mainly in research setting. In the present study, response was assessed by comparing magnetic resonance enterography global score (MEGS) pre- and post-therapy [20]. MEGS estimates the disease burden of small and large intestines (total 9 segments) including mural and extramural features. MEGS was calculated by identifying the involved area of each segment, then grading the findings like mural thickness, mural enhancement, T2 signal of mural and peri mural and T1 enhancement and multiplying the score with factor of involved segments. Additional points for extramural features like lymph nodes, coombs sign, abscess, and fistulae would be calculated for each segment. Final score would be calculated by summing up all the scores of individual segments with maximum possible score of 296 (Supplementary Tables 1, 2).

7. Outcomes

Primary outcome of the study was to determine the proportion of patients having clinical response and remission at 2 months and 6 months of HBOT. Other outcomes included steroid-free clinical response rates on follow up, adverse events due to HBOT, improvement in quality of life as assessed by SIBD and imaging response at 6 months. SIBD questionnaire was shorter and easily calculated. It includes 4 domains including disease related bowel and systemic symptoms, physical, emotional and social wellbeing with each subdomain scored by Likert scale (range, 1-7). Total score ranges from 10 (worst) to 70 (best) which can be calculated by patient himself and requires less than 10 minutes for completion.

8. Statistical Analysis

Data were explored for any outliers, typing errors, and missing values. For categorical variables frequency and the percentage were calculated, and continuous variables were expressed as mean ± standard deviation or median (range) as appropriate. Student t-test was used for comparing continuous variables between the groups. Fisher exact test was used for comparing qualitative data. A P-value of 0.05 was considered significant. All the data were analyzed using the SPSS software version 21 (IBM Corp., Armonk, NY, USA).

9. Ethical Approval and Informed Consents

The protocol was approved by the Ethics Committee of All India Institute of Medical Sciences, New Delhi (approval No. IECPG-219/27.03.2019). Informed and written consent was obtained from each participant of the study. We followed STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines.

RESULTS

From April 2019 till January 2020, 30 patients of small bowel stricturing and internal fistulizing CD who were refractory to conventional treatment were screened. Fourteen of them were finally enrolled after fulfilling all inclusion criteria and ruling out contraindications for HBOT (Fig. 1).

1. Baseline Characteristics

Mean age of the patients was 42.9 ± 15.7 years and 50% were male. The median duration of disease was 114 months (range, 46-174 months). All patients had stricturing disease and 1 patient had associated enterocutaneous fistula. None of the patients had a perianal fistula. Two patients (14.3%) had extraintestinal manifestations of IBD (Table 1).

2. Treatment History

Most of the patients had received steroids (85.7%) and immunomodulators (azathioprine or 6-mercaptopurine, 78.6%; methotrexate, 42.9%). Eight patients (57.1%) received anti-TNF therapy but did not respond or had loss of response. One patient underwent small bowel resection in past. Only 2 patients had received concomitant immunosuppression while receiving HBOT (1 betamethasone and 1 methotrexate). Twelve patients (85.7%) were given HBOT without any accompanying immunosuppressive therapy (Table 1). None of the patients had kept fasting with central venous nutrition and received steroids during the HBOT. Among 5 patients who did not have response to HBOT, 1 patient had surgery, another patient received sirolimus, and rest of the patients who were anti-TNF naive received anti-TNFs.

3. Hyperbaric Oxygen Therapy

Median number of HBOT sessions received per patient was 11 (range, 3-20), and each session lasted for 60 minutes. The overall median duration of therapy was 4 weeks ranging from 1 week to 8 weeks (Table 2).

4. Efficacy

At 2 months of follow-up, 9 patients (64.2%) had a clinical response, 7 patients (50%) had clinical remission, and 8 patients (57.1%) had a steroid-free clinical response. At 6 months of follow-up, 9 patients (64.2%) had clinical remission and 8 patients (57.1%) maintained steroid-free clinical response as shown in Table 3 and Supplementary Fig. 1. There was significant improvement in SIBD scores at 2 months follow-up (59.4 vs. 44.5, P=0.03) and with a trend towards improvement at 6 months (54 vs. 44.5, P=0.07) (Table 4). There was some improvement in hemoglobin level (10.4 ± 3.4 g/dL at 6 months vs. 8.7 ± 2.2 g/dL at baseline, P=0.09) which was not statistically significant. There was no improvement in serum albumin level. One patient with stricture and enterocutaneous fistula had no improvement in fistula output post-therapy after receiving 15 sessions of HBOT.
Magnetic resonance enterography was done in 8 patients who had clinical response on 6 months of follow-up and was compared with the baseline imaging. Four patients (50%) had improvement in scores whereas 3 patients (37.5%) had stable MEGS scores and 1 patient (12.5%) had worsening of disease activity post-therapy on imaging (Tables 5 and 6, Fig. 2).

5. Tolerability

Twelve patients (85.7%) tolerated the therapy well without any side effects and 2 patients had therapy-related adverse effects. One patient had hemotympanum in the right ear while receiving 3rd session at 2 atm pressure because of which therapy was discontinued. Hemotympanum was managed conservatively by nasal decongestants and antibiotic ear drops and the patient’s ear pain improved in 1 week. Another patient had right earache while receiving 7th session at 2.5 atm. ENT examination showed normal tympanic membrane. After discontinuing therapy for 3 days and treatment with nasal decongestants, the patient was restarted on HBOT at 2 atm pressure and received 8 more sessions of HBOT without any problem. No patients in our study reported claustrophobia.

DISCUSSION

Immune mediated inflammatory damage induced epithelial disruption in IBD leads to epithelial hypoxia as a result of increased oxygen demand (due to immune cell infiltrate) and reduced oxygen supply (due to vascular dysfunction), which activates downstream inflammatory signaling, perpetuating the inflammation. Mechanistically, increasing tissue oxygen levels could halt this progression and the present study explored this hypothesis in a cohort of difficult to treat patients with CD.
HBOT showed promising results in treating patients with stricturing CD who were already refractory to medical treatment (more than 50% of patients even failed anti-TNF therapy). Rates of clinical remission and steroid-free remission at 2 months of follow-up were 50% and 57.1% respectively while at 6 months, they were 64.2% and 57.1% respectively. Moreover, these patients did not require any treatment change during this follow-up period. There was a significant improvement in the patient-reported outcome as well, and this persisted even 6 months post-therapy. The largest evidence till date on the efficacy of HBOT in IBD is the 2014 systematic review which included 17 studies (613 patients; 327 UC and 286 CD), and reported excellent response rates in both CD and UC patients (> 80%). However, of 613 patients, 519 were included from a Russian study (277 UC and 242 CD) which did not report about the characteristics of CD patients. Of the other 44 CD patients (14 patients in the largest series), 42 had perianal/non-perianal fistulizing disease, and of these 80% had a clinical response [11]. However, there are no reports on the efficacy of HBOT in patients with stricturing CD, and the present study for the first time had demonstrated the role of HBOT in these patients. Lower response rates in the present study (64% vs. 80%) as compared to the systematic review could be due to different disease behavior and lower number of HBOT sessions.
In addition to clinical response, we also evaluated the radiologic response in a subgroup of patients. Except for a case report of 2 patients with CD, prior studies of HBOT in IBD patients did not evaluate the radiologic response, instead, they looked for clinical and endoscopic responses. We used MEGS to assess the response on imaging. MEGS has been prospectively validated against the gold standard of Harvey-Bradshaw index, fecal calprotectin, and C-reactive protein [20]. However, we did not find any significant radiologic improvement. A possible explanation for this disparity between clinical and radiologic response could be contributed by the lesser number of HBOT sessions, which could only have partially reversed the bowel damage and was insufficient to cause mucosal healing. Further studies with a larger number of HBOT sessions could prove more efficacious and could cause improvements in radiological as well as biochemical parameters.
Recent studies have demonstrated the efficacy of HBOT in other indications such as refractory pouchitis and acute severe colitis. Two recent studies reported good response to HBOT in 21 and 43 patients, respectively, with refractory pouchitis, and in 1 of these studies 7 out of 9 patients (77.8%), with fistulizing pouch complications, had significant clinical and endoscopic improvement. However, average number of HBOT sessions was 30 in both these studies, which was much higher than what we had used [13,21]. The systematic review by Dulai et al. [11] showed significant clinical improvement and reduction in colectomy rates with HBOT therapy in patients with UC admitted with moderate to severe flares. Further, recent randomized trials have demonstrated improvement in steroid response rates and reduction in need for rescue medical therapy/colectomy in patients with acute severe colitis [12].
In our study 2 patients (14.7%) (2 adverse events/total 168 HBOT sessions) had adverse events while receiving HBOT, 1 had hemotympanum requiring discontinuation of therapy and the other had earache without any discontinuation of therapy. The systematic review reported 9 adverse events over 8,924 HBOT treatments, of which 6 required treatment discontinuations. The reported adverse events included barotrauma, psychological intolerance and blurred vision [11]. Recent studies have not reported any serious adverse events [11,13]. A possible explanation for higher rates in our cohort could be the method of delivering HBOT, we did not use air brake during the procedure which lasted for a maximum of 60 minutes duration, whereas other studies have used air brakes of 10-15 minutes during the session of HBOT. These air brakes may prevent the barotrauma to the middle ear. We did not find any psychological intolerance or other adverse events in our study.
This study was done as a proof of concept study, provides a basis for larger studies with randomized design for impactful conclusions. All these patients included in the study were refractory to other medical treatments with limited alternative therapeutic options available. Another strength of our study was the assessment of imaging response pre- and post-therapy.
Despite some early promising result, this study was limited by small sample size and a lesser number of HBOT sessions when compared to other studies. Duration of follow-up in our patients was also limited to 6 months. These patients need to be followed up for a longer duration to assess the durability of the beneficial effects of HBOT.
In conclusion, HBOT can be offered to patients of stricturing CD who are refractory to other medical therapy and not candidates for surgery. We need well-designed randomized controlled trials or prospective study with larger sample size, more sessions and longer duration of follow-up to further validate this result.

ADDITIONAL INFORMATION

Funding Source

The authors received no financial support for the research, authorship, and/or publication of this article.

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Author Contribution

Conceptualization: Ahuja V. Methodology: Ahuja V, Kedia S, Kante B, Sahu P, Singhal M, Sharma R, Soni K, Makharia G, Vuyyuru SK. Formal analysis: Kante B, Sahu P, Vuyyuru SK, Kedia S. Project administration: Ahuja V, Kante B, Kedia S, Soni K, Singhal M. Visualization: Kante B, Ahuja V, Kedia S, Sharma R, Makharia G. Writing original draft: Kante B, Sahu P, Kedia S. Writing, review and editing: Kante B, Sahu P, Kedia S, Vuyyuru SK, Ahuja V, Makharia G, Sharma R. Approval of final manuscript: all authors.

Others

We are particularly grateful to our patients, colleagues, nursing, pharmacy, clerical staff and allied professionals who collectively support our IBD services and enable studies such as this to be performed.

Supplementary Material

Supplementary materials are available at the Intestinal Research website (https://www.irjournal.org).
Supplementary Table 1. MRI Response Was Calculated by Comparing MEGS Score Pre- and Post-Therapy
ir-2021-00056-suppl1.pdf
Supplementary Table 2. Additional Score for Extramural Features in Calculation of MEGS
ir-2021-00056-suppl2.pdf
Supplementary Fig. 1. Pictorial analysis of individual Crohn’s Disease Activity Index (CDAI) scores at baseline, 2 months, and 6 months.
ir-2021-00056-suppl3.pdf

Fig. 1.
Consort chart. CD, Crohn’s disease; HBOT, hyperbaric oxygen therapy.
ir-2021-00056f1.jpg
Fig. 2.
Magnetic resonance enterography images. (A) T1 weighted contrast image of a patient showing ileal stricture with proximal dilatation and marked enhancement (pre-HBOT) calculated MEGS score 7. (B) T1 weighted contrast image of a patient showing ileal stricture with proximal dilatation and reduced enhancement (post 6 months of HBOT) compared to (A) calculated MEGS score 5. HBOT, hyperbaric oxygen therapy; MEGS, magnetic resonance enterography global score.
ir-2021-00056f2.jpg
Table 1.
Baseline Demographics, Disease Phenotypes and Characteristics of Stricturing Crohn’s Disease Undergoing HBOT Therapy
Characteristics Frequency (n = 14)
Age (yr) 42.9 ± 15.7
Sex
 Male 7 (50.0)
 Female 7 (50.0)
Age at onset (yr) 33.4 ± 16.2
Disease duration (mo) 114 (46-174)
Family history 0
Smoking 0
Disease behavior
 B2 13 (92.8)
 B3 1 (7.2)
Disease location
 L1 4 (28.6)
 L2 0
 L3 1 (7.1)
 L4 2 (14.3)
 L1+4 6 (42.9)
 L3+4 1 (7.1)
EIM 2 (14.3)
Perianal fistula 0
Treatment history
 Steroids 12 (85.7)
 No. of steroid courses 3 (0-6)
 Azathioprine or 6-MP 11 (78.6)
 Methotrexate 6 (42.9)
 Anti-TNF 8 (57.1)
 Exclusive enteral nutrition 8 (57.1)
 Endoscopic dilatation 0
 Prior surgery 1 (7.2)
Baseline CDAI 252 (165-396)
Hemoglobin (gm/dL) 8.7 ± 2.2
Serum albumin (gm/dL) 3.1 ± 0.9

Values are presented as mean±standard deviation, number (%), or median (interquartile range).

HBOT, hyperbaric oxygen therapy; EIM, extraintestinal manifestation; 6-MP, 6-mercaptopurine; TNF, tumor necrosis factor; CDAI, Crohn’s Disease Activity Index.

Table 2.
Details of Hyperbaric Oxygen Therapy
Variable Value
No. of sessions 11 (3-20)
Duration of each session (min) 60
Pressure delivered (atm)a 1.5-2.5
Duration of therapy (wk) 4 (1-8)
Therapy-related adverse effects 2 (14.3)
Adverse effect leading to discontinuation of therapy 1 (7.1)
Patients who received concomitant medical therapy
 Betamethasone 1 (7.1)
 Methotrexate 1 (7.1)
 Total 2 (14.3)

Values are presented as the median (interquartile range) or number (%).

a Range.

Table 3.
Response to Hyperbaric Oxygen Therapy
Response No. (%)
At 2 months
 Clinical response 9 (64.2)
 Clinical remission 7 (50.0)
 Steroid-free clinical response 8 (57.1)
At 6 months of follow-up
 Clinical response 9 (64.2)
 Clinical remission 9 (64.2)
 Steroid-free clinical response 8 (57.1)
Table 4.
Changes in Short Inflammatory Bowel Disease Questionnaire Score
Baseline HBOT
2 Months 6 Months
Median (IQR) 44.5 (20-60) 59.5 (40-64) 54.0 (33-62)
P-value 0.03 0.07

HBOT, hyperbaric oxygen therapy; IQR, interquartile range.

Table 5.
MRI Comparison Pre- and Post-HBOT after 6 Months (Calculated by MEGS)
Variable Patient No.
1 2 3 4a 4b 5 6 7 8
No. of segment Pre-therapy 11 5 4 2 4 3 3 10 3
Post-therapy 12 5 4 3 5 3 3 10 2
Length of segment Pre-therapy 1.5 1.1 1.1 1.2 5 1.2 1.4 2 8
Post-therapy 1.5 9.5 1.1 1.2 5 0.8 1.2 1.7 9
Mural thick Pre-therapy 1 2 1 1 1 1 1 2 3
Post-therapy 1 1 1 1 2 1 1 1 3
Mural T2 signal Pre-therapy 1 2 2 2 2 1 2 2 3
Post-therapy 1 1 2 2 2 1 2 2 3
Peri mural T2 signal Pre-therapy 1 1 2 2 2 1 1 2 2
Post-therapy 1 2 1 1 2 1 1 2 2
T1 enhancement Pre-therapy 1 2 2 2 2 2 2 2 2
Post-therapy 1 2 1 2 2 2 2 2 2
Mural enhancement pattern Pre-therapy 2 0 0 1 1 2 1 2 2
Post-therapy 2 1 0 0 1 1 0 2 2
Coombs sign Pre-therapy 0 0 0 0 1 0 0 5 1
Post-therapy 0 0 0 0 1 0 0 5 1
Total score Pre-therapy 6 7 7 21 7 5 15 23
Post-therapy 6 9 5 20 6 4 15 23

a Calculated for jejunal strictures.

b Calculated for ileal strictures.

MRI, magnetic resonance imaging; HBOT, hyperbaric oxygen therapy; MEGS, magnetic resonance enterography global score.

Table 6.
Trends in Scores of CDAI and MEGS in Patients Who Had Clinical Response
Patient No. No. of HBOT sessions CDAI
MEGS
Baseline 2 Months 6 Months Baseline 6 Months
1 10 217 130 97 6 6
2 10 165 140 133 7 9
3 15 209 298 109 7 5
4 20 334 65 288 21 20
5 15 203 150 147 7 6
6 10 271 126 149 5 4
7 15 270 50 72 15 15
8 15 209 118 149 23 23

CDAI, Crohn’s Disease Activity Index; MEGS, magnetic resonance enterography global score; HBOT, hyperbaric oxygen therapy.

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