| The Frequency and Clinical Manifestation of Post-Infectious IBS (PI-IBS) in Patients with Intestinal Tuberculosis |
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Jong-Soo Lee, Sung-Ae Jung, Hye Jung Yeom, Yoo Kyung Cho, Seong-Eun Kim, Si Nae Lee, Il Hwan Moon |
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Department of Internal Medicine, Ewha Womans University College of Medicine, Ewha Medical Research Institute, Pathology, Seoul, Korea
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| 장결핵 환자에서 감염후 과민성 장증후군의 발생빈도와 임상양상 |
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이종수, 정성애, 염혜정, 조유경, 김성은, 이시내, 문일환 |
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이화여자대학교 의과대학 내과학교실, 의과학연구소, 해부병리과 |
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| Abstract |
Background/Aims
The purpose of this study is to investigate the prevalence of PI-IBS after intestinal tuberculosis and the correlation of serotonin-containing EC cell and PI-IBS after intestinal tuberculosis. Methods: We reviewed the medical records of 14 patients with intestinal tuberculosis between January, 2001 and September, 2002. The diagnosis of PI-IBS was based on Rome II criteria. We performed immunohistochemical stain of serotonin antibody on colonoscopic biopsy specimens from 14 patients with tuberculosis and 11 asymptomatic controls. Results: Eight (58%) of 14 intestinal tuberculosis patients had no symptom and 3 patients (21%) had persistent IBS by Rome II criteria. Three patients with PI-IBS were all male. The severity of lesion by colonoscopy was severe in patients with PI-IBS (p＜0.05). Serotonin-containing EC cell counts were higher in 14 patients with intestinal tuberculosis compared with 11 patients of normal controls (8.4/HPF vs. 0.2/HPF, p＜0.05) and increased EC cells persisted after treatment of tuberculosis. Conclusions: PI-IBS was increased in patients with severe intestinal tuberculosis by colonoscopy. Serotonin-containing EC cells were increased in patients with intestinal tuberculosis. (Intest Res 2005;3:55-60) |
| Key Words:
Intestinal tuberculosis, Post-infectious irritable bowel syndrome, Serotonin |
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