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Intestinal Research 2005;3(1):55-60.
Published online June 30, 2005.
The Frequency and Clinical Manifestation of Post-Infectious IBS (PI-IBS) in Patients with Intestinal Tuberculosis
Jong-Soo Lee, Sung-Ae Jung, Hye Jung Yeom, Yoo Kyung Cho, Seong-Eun Kim, Si Nae Lee, Il Hwan Moon
Department of Internal Medicine, Ewha Womans University College of Medicine, Ewha Medical Research Institute, Pathology, Seoul, Korea
장결핵 환자에서 감염후 과민성 장증후군의 발생빈도와 임상양상
이종수, 정성애, 염혜정, 조유경, 김성은, 이시내, 문일환
이화여자대학교 의과대학 내과학교실, 의과학연구소, 해부병리과
Abstract
Background/Aims
The purpose of this study is to investigate the prevalence of PI-IBS after intestinal tuberculosis and the correlation of serotonin-containing EC cell and PI-IBS after intestinal tuberculosis. Methods: We reviewed the medical records of 14 patients with intestinal tuberculosis between January, 2001 and September, 2002. The diagnosis of PI-IBS was based on Rome II criteria. We performed immunohistochemical stain of serotonin antibody on colonoscopic biopsy specimens from 14 patients with tuberculosis and 11 asymptomatic controls. Results: Eight (58%) of 14 intestinal tuberculosis patients had no symptom and 3 patients (21%) had persistent IBS by Rome II criteria. Three patients with PI-IBS were all male. The severity of lesion by colonoscopy was severe in patients with PI-IBS (p<0.05). Serotonin-containing EC cell counts were higher in 14 patients with intestinal tuberculosis compared with 11 patients of normal controls (8.4/HPF vs. 0.2/HPF, p<0.05) and increased EC cells persisted after treatment of tuberculosis. Conclusions: PI-IBS was increased in patients with severe intestinal tuberculosis by colonoscopy. Serotonin-containing EC cells were increased in patients with intestinal tuberculosis. (Intest Res 2005;3:55-60)
Key Words: Intestinal tuberculosis, Post-infectious irritable bowel syndrome, Serotonin
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