| The Changes of Intestinal Permeability in Patients with Acute Viral Hepatitis B and Toxic Hepatitis |
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Jeong Wook Kim, Woo Kyu Jeon |
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Department of Internal Medicine, Chungang University College of Medicine, Seoul, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
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| 급성 B형 바이러스성 간염 및 독성 간염 환자에서의 장투과성의 변화 |
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김정욱, 전우규 |
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중앙대학교 의과대학 내과학교실, 성균관대학교 의과대학 강북삼성병원 내과 |
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| Abstract |
Background/Aims
The changes of intestinal permeability have been investigated in patients with chronic liver disease such as alcoholic liver disease. However, the changes of intestinal permeability had not been reported in patients with acute hepatitis except acute hepatitis A. This study aimed to investigate the changes of intestinal permeability and examine correlations between the intestinal permeability and clinical characteristics in patients with acute hepatitis. Methods: The intestinal permeability were measured in 15 normal heathy controls, 30 patients with acute hepatitis (acute hepatitis B 15 , acute toxic hepatitis 15) by measuring 24 hour urine excretion of 51Cr-EDTA (51Cr-ethylenediaminetetraacetic acid) for evaluation of the gut barrier dysfunction. We compared the intestinal permeability with clinical characteristics of patients. Results: The increase in intestinal permeability in patients with acute hepatitis B was more higher than patients with acute toxic hepatitis (p＜0.05). The increase in intestinal permeability showed significant correlation with erythrocyte sedimentation rate and prothrombin time (p＜0.05). Conclusions: The increase in intestinal permeability was more in patients with acute hepatitis B than acute toxic hepatitis and may be related to erythrocyte sedimentation rate and prothrombin time. (Intest Res 2005;3:74-79) |
| Key Words:
Permeability, intestine, Hepatitis B, Hepatitis, toxic, Prothrombin time, Erythrocyte sedimentation rate |
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