Two Cases of Crohn's Disease Presented with Hematochezia in Patients with Hemophilia |
Jae Hyun Park, Hyo Jong Kim, Seong Dong Sohn, Young Hwangbo, Jaejun Shim, Jae Young Jang, Seok Ho Dong, Byung Ho Kim, Young Woon Chang, Rin Chang |
Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea
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혈우병 환자에서 발생한 혈변으로 진단된 크론병 2예 |
박재현, 김효종, 손성동, 황보영, 심재준, 장재영, 동석호, 김병호, 장영운, 장린 |
경희대학교 의과대학 내과학교실 |
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Abstract |
The etiology of Crohn's disease, which is a chronic inflammatory condition that potentially involves any location of the alimentary tract from the mouth to the anus, is unknown. However, there is strong evidence that vascular damage could play a role in the pathogenesis of Crohn's disease. Crohn's disease is mediated by multifocal gastrointestinal infarctions, which occur at an early stage in the disease process. Persistent activation of coagulation in patients with Crohn's disease has been shown. In contrast, hemophilia is an inherited disorder of coagulation. The deficiencies of clotting factors usually involve occult or overt bleeding. The pathogenic mechanisms of Crohn's disease and hemophilia are incompatible. An association between Crohn's disease and hemophilia has not been reported in Korea. We managed 21- and 33-year-old men with Crohn's disease associated with hemophilia, who presented with hematochezia. (Intest Res 2011;9: 9-39) |
Key Words:
Crohn's Disease, Hemophilia, Inflammatory Bowel Diseases |
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