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Intest Res > Volume 9(2); 2011 > Article
Intestinal Research 2011;9(2):90-96.
DOI: https://doi.org/10.5217/ir.2011.9.2.90    Published online August 30, 2011.
Molecular Imaging of Gastrointestinal Malignancies
Jong Wook Kim, Soon Man Yoon, Seung-Jae Myung
Division of Gastroenterology, Asan Digestive Disease Research Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea
소화기암의 분자 영상
김정욱, 윤순만, 명승재
울산대학교 의과대학 서울아산병원 소화기내과학교실, 아산 소화기병 연구소, 충북대학교 의과대학 내과학교실
Abstract
Endoscopic detection of gastrointestinal cancer currently depends in large part on white light images, which show mucosal surface changes in real time. Molecular imaging is a rapidly growing new field in gastrointestinal endoscopy, which could provide additional information about molecular expression of cells and processes involved in cancer biology. It uses the molecular signature of cells for minimally-invasive, targeted imaging of gastrointestinal pathologies. Exogenous fluorescent agents serve as molecular beacons and include labeled peptides and antibodies, and probes with tumor-specific activation. An advantage of molecular imaging in digestive tract is the opportunity to apply such agents topically, overcoming the hurdles for delivery of these agents to the region of involvement, including immunogenic reaction and potential toxicity. Recently developed molecular targets include proteolytic enzymes, endothelial-specific markers, and apoptosis reporters. Molecular imaging has the potential to greatly impact on future endoscopy in gastroenterology. (Intest Res 2011;9:90-96)
Key Words: Molecular Imaging, Gastrointestinal Neoplasms, Biomarkers
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