Intestinal Research

Yogesh Gupta

2 Articles

Inflammatory bowel diseases

Incidental benefits after fecal microbiota transplant for ulcerative colitis: Ramit Mahajan, Vandana Midha, Arshdeep Singh, Varun Mehta, Yogesh Gupta, Kirandeep Kaur, Ritu Sudhakar, Anmol Singh Pannu, Dharmatma Singh, Ajit Sood; Intest Res 2020;18(3):337-340. Published online April 22, 2020; DOI: https://doi.org/10.5217/ir.2019.00108

Gut dysbiosis can result in several diseases, including infections (Clostridium difficile infection and infectious gastroenteritis), autoimmune diseases (inflammatory bowel disease, diabetes, and allergic disorders), behavioral disorders and other conditions like metabolic syndrome and functional gastrointestinal disorders. Amongst various therapies targeting gut microbiome, fecal microbiota transplantation (FMT) is becoming a focus in the public media and peer reviewed literature. We have been using FMT for induction of remission in patients with moderate to severe active ulcerative colitis (UC) and also for subsequent maintenance of remission. Four cases reported incidental benefits while being treated with FMT for UC. These included weight loss (n=1), improvement in hair loss (n=1), amelioration of axial arthritis (n=1) and improvement in allergic rhinitis (n=1), thereby suggesting potential clinical applications of FMT in treating extraintestinal diseases associated with gut dysbiosis.

Citations

Citations to this article as recorded by

Fecal microbiota transplantation in allergic diseases
Ece Tüsüz Önata, Öner Özdemir
World Journal of Methodology.2025;[Epub] CrossRef
α‐Lipoic acid alleviates dextran sulfate sodium salt‐induced ulcerative colitis via modulating the Keap1–Nrf2 signaling pathway and inhibiting ferroptosis
Peng Jiang, Zongzhen Zhai, Linxian Zhao, Kai Zhang, Liwei Duan
Journal of the Science of Food and Agriculture.2024; 104(3): 1679. CrossRef
Effects of dietary imbalances of micro- and macronutrients on the ocular microbiome and its implications in dry eye disease
Madeline Pilkington, Declan Lloyd, Brad Guo, Stephanie L. Watson, Kenneth Gek-Jin Ooi
Exploration of Medicine.2024; : 127. CrossRef
Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease
Seung Yong Shin, Young Kim, Won-Seok Kim, Jung Min Moon, Kang-Moon Lee, Sung-Ae Jung, Hyesook Park, Eun Young Huh, Byung Chang Kim, Soo Chan Lee, Chang Hwan Choi
Intestinal Research.2023; 21(1): 148. CrossRef
Case report: Fecal microbiota transplantation in refractory ankylosing spondylitis
Lei Wang, Zhimin Wei, Fei Pan, Chuan Song, Lihua Peng, Yunsheng Yang, Feng Huang
Frontiers in Immunology.2023;[Epub] CrossRef
Gut-spine axis: a possible correlation between gut microbiota and spinal degenerative diseases
Tadatsugu Morimoto, Takaomi Kobayashi, Toshihiko Kakiuchi, Motohiro Esaki, Masatsugu Tsukamoto, Tomohito Yoshihara, Hirohito Hirata, Shoji Yabuki, Masaaki Mawatari
Frontiers in Microbiology.2023;[Epub] CrossRef
Gut microbiota changes in patients with spondyloarthritis: A systematic review
Lei Wang, Yiwen Wang, Pei Zhang, Chuan Song, Fei Pan, Gang Li, Lihua Peng, Yunsheng Yang, Zhimin Wei, Feng Huang
Seminars in Arthritis and Rheumatism.2022; 52: 151925. CrossRef
Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases
Yun Wang, Sheng Zhang, Thomas J. Borody, Faming Zhang
Chinese Medical Journal.2022;[Epub] CrossRef
Clinical Application and Progress of Fecal Microbiota Transplantation in Liver Diseases: A Review
Xinpei Gu, Qin Lu, Chengcheng Zhang, Zhewei Tang, Liuxi Chu
Seminars in Liver Disease.2021; 41(04): 495. CrossRef
Intestinal microbiota and inflammatory bowel diseases
Chang Soo Eun
Journal of the Korean Medical Association.2021; 64(9): 588. CrossRef

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Miscellaneous

Clinical profile and outcomes of opioid abuse gastroenteropathy: an underdiagnosed disease entity: Ramit Mahajan, Yogesh Gupta, Arshdeep Singh, Pulkit Dhiman, Vandana Midha, Chandan Kakkar, Vikram Narang, Varun Mehta, Kavita Saggar, Ajit Sood; Intest Res 2020;18(2):238-244. Published online February 25, 2020; DOI: https://doi.org/10.5217/ir.2019.00104

Abstract PDF PubReader ePub

Background/Aims
Opioid-induced bowel dysfunction includes nausea, vomiting, constipation and abdominal distension. We describe patients presenting with gastrointestinal (GI) ulcers and ulcerated strictures secondary to opioid abuse, an entity not well described in literature.
Methods
This retrospective observational study included patients with opioid abuse gastroenteropathy presenting to Dayanand Medical College and Hospital, Ludhiana, India between January 2013 and December 2018. Opioid abuse gastroenteropathy was defined as gastric or small bowel ulcers and ulcerated strictures in patients abusing opioids, where all other possible etiologies of GI ulcers/strictures were excluded. Clinical, biochemical, endoscopic, radiological and histological parameters as well as response to treatment were assessed.
Results
During the study period, 20 patients (mean age, 38.5±14.2 years; 100% males) were diagnosed to have opioid induced GI ulcers and/or ulcerated strictures. The mean duration of opioid consumption was 6.2±3.4 years. The mean duration of symptoms at presentation was 222.1±392.3 days. Thirteen patients (65%) had gastroduodenal involvement, 6 (30%) had a jejunoileal disease and 1 (5%) had an ileocecal stricture. Two patients (10%) presented with upper GI bleeding, 11 (55%) had features of gastric outlet obstruction and 7 (35%) presented with small bowel obstruction. Abdominal pain and iron deficiency anemia were the most common presentations. Only 1 patient (5%) responded to proton pump inhibitors, 3 (15%) had a lasting response to endoscopic balloon dilatation, while all other (80%) required surgical intervention.
Conclusions
Opioid abuse gastroenteropathy presents as ulcers and ulcerated strictures which respond poorly to medical management and endoscopic balloon dilatation. A majority of these cases need surgical intervention.

Citations

Citations to this article as recorded by

Peptic ulcer characteristics in oral opium and non-opium user patients with upper gastrointestinal bleeding
Mohsen Masoodi, Mohammad Sabzikarian, Nikta Masoodi, Saeed Farhadi, Gholam Reza Rezamand, Seidamir Pasha Tabaeian, Atefeh Talebi, Farimah Fayyaz
BMC Gastroenterology.2024;[Epub] CrossRef
Cryptogenic multifocal ulcerous stenosing enteritis: A ray of light on the umbra of the dark continent
Mithu Bhowmick, Vishal Sharma
Indian Journal of Gastroenterology.2024; 43(6): 1082. CrossRef
Adult‐onset megacolon with focal hypoganglionosis: A detailed phenotyping and prospective cohort study
Jiyoung Yoon, Kee Wook Jung, Nam Seok Ham, Jihun Kim, Yoon Suh Do, Seon Ok Kim, Sang Hyun Choi, Dong Wook Kim, Sung Wook Hwang, Sang Hyoung Park, Dong‐Hoon Yang, Byong Duk Ye, Jeong‐Sik Byeon, Yong Sik Yoon, Chan Wook Kim, Chang Sik Yu, Hwoon‐Yong Jung, S
Neurogastroenterology & Motility.2023;[Epub] CrossRef
Endogenous opiates and behavior: 2020
Richard J. Bodnar
Peptides.2022; 151: 170752. CrossRef

9,382 View
174 Download
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