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Intest Res > Volume 10(3); 2012 > Article
Intestinal Research 2012;10(3):289-294.
DOI: https://doi.org/10.5217/ir.2012.10.3.289    Published online July 31, 2012.
Recurrent Acute Pericarditis Induced by 5-aminosalicylates in a Patient with Inflammatory Bowel Disease
A Ra Choi, Mi Na Kim, Ji Hoon Lee, Yong Kang Lee, Yoon Hea Park, Hye Sun Shin, Tak Geun Oh, Hee Jin Park, Min Suk Park, Seungtaek Lim, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, Jae Hee Cheon
Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
염증성 장질환에서 5-aminosalicylate에 의해 발생한 재발성 급성 심낭염
최아라, 김미나, 이지훈, 이용강, 박윤혜, 신혜선, 오탁근, 박희진, 박민석, 임승택, 박수정, 홍성필, 김태일, 김원호, 천재희
연세대학교 의과대학 내과학교실, 소화기병연구소
Abstract
Inflammatory bowel disease (IBD) is an idiopathic chronic inflammation of the intestines. IBD treatment may require anti-inflammatory agents such as sulfasalazine or 5-aminosalicylate (5-ASA) and immunomodulators to control the symptoms. However, these agents have a variety of common adverse effects such as nausea, vomiting, skin rash, leukopenia, thrombocytopenia, and infections. Moreover, rare side effects such as nephrotic syndrome, pneumonitis, and pericarditis can occur. A 21-year-old male was admitted to the hospital due to acute chest pain, fever, and sweating. The patient had a history of Crohn's disease and had been taking mesalazine for 3 weeks. Chest x-ray, echocardiography, and clinical manifestations revealed that the patient had acute pericarditis. However, we did not recognize the relationship between these findings and 5-ASA at that time. Two years later, the patient took 5-ASA again, and similar symptoms occurred, which led us to confirm that he suffered from pericarditis induced by this drug. We report a case of acute recurrent pericarditis that developed after taking 5-ASA for IBD treatment with a review of the literature. (Intest Res 2012;10: 0-294)
Key Words: Crohn Disease, Colitis, Ulcerative, Mesalamine, Pericarditis
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